The Perryville Fire Department responded Monday to a 7:15 a.m. call reporting a flue fire at a home in the 1000 block of County Road 316 in Perry County.
Upon their arrival, firefighters discovered a man in his 70s dead inside the house.
While battling the fire, the home's main floor reportedly collapsed into the basement.
The Missouri State Fire Marshal has been called in to investigate the cause of the fire, which is currently undetermined.
The house is considered a total loss. No other injuries were reported.
Assisting the Perryville Fire Department were Perry County Rural and the Chester Fire Department.